Detalhe da pesquisa
1.
Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors-New Usnic Acid Derivatives.
Int J Mol Sci
; 25(2)2024 Jan 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38279210
2.
New Dual Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 and 2 Based on Deoxycholic Acid: Design, Synthesis, Cytotoxicity, and Molecular Modeling.
Molecules
; 29(3)2024 Jan 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-38338326
3.
Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1.
Int J Mol Sci
; 24(6)2023 Mar 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-36982848
4.
Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties.
Int J Mol Sci
; 24(4)2023 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36835244
5.
New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan.
Int J Mol Sci
; 24(11)2023 May 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-37298106
6.
Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking.
Bioorg Med Chem Lett
; 73: 128909, 2022 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35907608
7.
In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions.
Molecules
; 27(8)2022 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35458631
8.
Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan.
Molecules
; 27(11)2022 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35684313
9.
New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1.
Int J Mol Sci
; 22(21)2021 Oct 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34768766
10.
New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2.
Molecules
; 27(1)2021 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35011303
11.
Discovery of Novel Sultone Fused Berberine Derivatives as Promising Tdp1 Inhibitors.
Molecules
; 26(7)2021 Mar 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33808389
12.
Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments.
Molecules
; 26(11)2021 May 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34073771
13.
The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme.
Int J Mol Sci
; 21(19)2020 Sep 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32998385
14.
Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides.
Molecules
; 25(16)2020 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32823658
15.
Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1.
Molecules
; 25(15)2020 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-32751997
16.
Design, Synthesis and Molecular Modeling Study of Conjugates of ADP and Morpholino Nucleosides as A Novel Class of Inhibitors of PARP-1, PARP-2 and PARP-3.
Int J Mol Sci
; 21(1)2019 Dec 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-31892271
17.
Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy.
Int J Mol Sci
; 21(1)2019 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31878088
18.
New Hydrazinothiazole Derivatives of Usnic Acid as Potent Tdp1 Inhibitors.
Molecules
; 24(20)2019 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31619021
19.
Aminoadamantanes containing monoterpene-derived fragments as potent tyrosyl-DNA phosphodiesterase 1 inhibitors.
Bioorg Chem
; 76: 392-399, 2018 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-29248742
20.
Novel group of tyrosyl-DNA-phosphodiesterase 1 inhibitors based on disaccharide nucleosides as drug prototypes for anti-cancer therapy.
J Enzyme Inhib Med Chem
; 33(1): 1415-1429, 2018 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30191738